RFICs
PRODUCTS
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For a nasal spray production fill-finish solution that offers unparalleled versatility, look no further! The Hull i-Dositecno BI and MI Nasal Spray Filling Machines simplify your manufacturing workflow to enable accurate and consistent rotary filling, stoppering and capping. With simple servo-driven motion-controlled design they can fill up to 50 or 200 units per minute (upm).
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Mikart’s development services include a range of pre-formulation capabilities for both oral solid and non-sterile oral liquid dose drug products.
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Building on the capabilities of the NP-RD10A benchtop tablet press (discussed in our previous article on USP <1062>), our services are further enhanced by the integration of the Presster™ compaction emulator. This state-of-the-art tool is designed to replicate the compaction dynamics of production tablet presses in a laboratory setting. It allows for tangible fine-tuning of the compression cycle, providing an accurate depiction of how a tablting formulation will behave under commercial manufacturing conditions. Using the Presster, Natoli Scientific can simulate full-scale production, permitting us to forecast problems before they escalate to costly production delays. Our experts can optimize the tablet design for our clients, ensuring a smooth transition from laboratory to production while adhering to the rigorous standards set by the industry including the current USP <1062> chapter.
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In the pharmaceutical industry, every capsule and tablet begins with a concept. Transforming that idea into a tangible product requires an expert manufacturing partner. Natoli stands out as a leader in pharmaceutical equipment and services, providing a comprehensive journey from formulation to full-scale production.
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The leading GIS-centric solution for permitting, licensing and land management—designed to simplify workflows for customers and staff. Improve public services and cross-team collaboration with a digital solution that keeps pace with the changes in your community.
WHITE PAPERS AND CASE STUDIES
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Outgrowing Excel: Implementing RTSM In A Live Phase I Trial
Learn how a clinical-stage oncology biotech successfully transitioned a live Phase I trial from manual spreadsheets to RTSM without disrupting site momentum or patient enrollment.
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What Unified eCOA And IRT Can Unlock
See how real-time scoring and automated eligibility checks helped a global dermatology study reduce site burden, avoid manual errors, and move participants through screening with greater speed.
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EHR-To-EDC Success In A Complex, Adaptive Platform Trial
I-SPY 2, one of the longest-running adaptive platform trials in oncology, is revolutionizing breast cancer research through a dynamic, data-driven approach to evaluating novel therapies.
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From Months To Hours: MMC Medical's EDC Revolution
Learn how a specialized CRO reduced study build times by 95%. Discover strategies for template reusability and flexible resource scaling to accelerate early-stage medical device validation.
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RO Membrane Protection For A Desalination Plant In Mejillones, Chile
Read about a seawater desalination plant that presented with several performance issues and chose the HOD UV system to control biofouling on the RO membranes.
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Multiple Fill Line Delivery Experience
Learn how a multinational pharmaceutical company successfully implemented a global strategy for insulin cartridge filling, achieving seamless regulatory approval with zero deviations.
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Drinking Water Disinfection At Lunenberg, Massachusetts, USA Local Community
In this case study, read how the Lunenburg Water District improved their water disinfection system with the installation of an Atlantium RZ300-11 HOD UV system. The system effectively disinfects water, meets future demands, and eliminates chlorine taste and odor.
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Automating The Process Of Filling Media Into Bottles
Learn how a vaccine manufacturer using a wide range of containers for media and buffer filling was able to increase efficiency by 70% with an automated closed-system solution.
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Rapid Development Of A Liquid-Filled Capsule Formulation Of CBD
Discover how we developed and tested multiple oral formulations in just three months, identifying a top candidate that outperformed existing standards in key performance metrics.
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Developing A Project Management Office (PMO) At A Small Manufacturing Site
Discover how implementing a Project Management Office transformed a small manufacturing site into a high-performing, strategic asset within a global network.
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Achieving A 2.67x Reduction In Study Build Time For An Innovative Neuromodulation Study
This study explores the potential of Focused Ultrasound Neuromodulation in deepening meditative states, and the platform that helps enhance the overall experience for researchers and participants alike.
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Enhancing Municipal Water Storage With Submersible Mixers: A Case Study
Ice accumulation in water tanks poses serious challenges, compromising operations by trapping volumes of water and potentially costing tens of thousands of dollars in infrastructure damage. PAX Mixers are highly effective in preventing ice formation, even in extreme cold conditions. By optimizing water circulation, we can maintain consistent water temperatures within a tank.
NEWS
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3-In-1 Orbital Thread Milling Cutters For New Thread Sizes1/14/2025
Following the successful introduction of the Thrill·tec TC645 Supreme orbital drill/thread mills for dimensions from M4 to M12 in 2023, Walter is now expanding its range to cover additional metric dimensions from M14 to M20 as well as their imperial equivalents.
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NX Filtration And Eau d'Azur Partner For Advanced Micropollutant Treatment In Nice8/25/2025
NX Filtration, a global leader in advanced hollow fiber membrane technology, is proud to announce its collaboration with Eau d’Azur, the public company responsible for drinking water and wastewater services for the Nice Côte d'Azur Metropole.
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Dielectric Partners With Foccus Digital For Brazilian Broadcast Growth8/15/2025
Dielectric’s Brazilian presence is about to radiate stronger through a new partnership with Foccus Digital that expand Dielectric’s broadcast business throughout the country.
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How Lakes Connect To Groundwater Critical For Resilience To Climate Change7/9/2025
The study drew on data from 350 lakes across 18 European countries, collected between 2022 and 2024, to provide a comprehensive picture of how the continent’s lakes are coping with climate change.
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Meatable And TruMeat Collaborate To Accelerate Cost-Effective Cultivated Meat Production4/30/2025
Meatable, the leader in cultivated meat technology, and TruMeat, specializing in the contract manufacturing of cultivated meat at commercial scale, have formed a strategic collaboration to advance the global commercialization of cultivated meat.
ABOUT
About Nutrient Removal
Nutrient removal from wastewater consists of treating wastewater to remove nitrogen and phosphorus before it reenters natural waterways. High levels of nitrogen and phosphorus in wastewater cause eutrophication, a process where excess nutrients stimulate excessive plant growth such as algal blooms and cyanobacteria. The decomposition of the algae by bacteria uses up the oxygen in the water causing other organisms to die. This creates more organic matter for the bacteria to decompose. In addition, some algal blooms can produce toxins that contaminate drinking water supplies.
As authorized by the Clean Water Act, the National Pollutant Discharge Elimination System (NPDES) permit program regulates point sources, such as municipal wastewater treatment plants, that discharge pollutants as effluent into the waters of the United States. In recent years, many of the States’ environmental bodies have lowered nutrient limits to arrest eutrophication. Maryland’s effort to protect the Chesapeake Bay and its tidal tributaries is perhaps the most notable example of nutrient removal in the US. Nutrient removal continues to be a growing area of focus for wastewater treatment throughout the world.
The removal of nitrogen and phosphorus require different nutrient removal processes. To remove nitrogen, the nitrogen is oxidized from ammonia to become nitrate through a process called nitrification. This process is then followed by denitrification where the nitrate is reduced to nitrogen gas which is released to the atmosphere and removed from the wastewater.
Nitrification is a two-step aerobic process which typically takes place in aeration tanks. Denitrification requires anoxic conditions to encourage the appropriate biological conditions to form. The activated sludge process is often used to reduce nitrate to nitrogen gas in anoxic or denitrification tanks.
Phosphorus can be removed biologically using polyphosphate accumulating organisms (PAOs) which accumulate large quantities of phosphorus within their cells and separate it from treated water. Phosphorus removal can also be achieved by chemical removal. Once removed as sludge, phosphorus may be stored in a land fill. However, many municipalities and treatment facilities are looking to resell the biosolids for use in fertilizer.