RFICs
PRODUCTS
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Optimize single-use solutions for cryopreservation by engaging in studies that focus on specific timepoints and conditions pertaining to therapy storage, containment/protection, and transportation.
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Building on the capabilities of the NP-RD10A benchtop tablet press (discussed in our previous article on USP <1062>), our services are further enhanced by the integration of the Presster™ compaction emulator. This state-of-the-art tool is designed to replicate the compaction dynamics of production tablet presses in a laboratory setting. It allows for tangible fine-tuning of the compression cycle, providing an accurate depiction of how a tablting formulation will behave under commercial manufacturing conditions. Using the Presster, Natoli Scientific can simulate full-scale production, permitting us to forecast problems before they escalate to costly production delays. Our experts can optimize the tablet design for our clients, ensuring a smooth transition from laboratory to production while adhering to the rigorous standards set by the industry including the current USP <1062> chapter.
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Natoli Scientific takes pride in its comprehensive USP<1062> Tablet Compression Characterization services, tailored to address the complexities of tableting in pharmaceutical manufacturing. Staying true to the parameters outlined in the United States Pharmacopeia (USP) Chapter 1062, our approach meticulously evaluates tablet compression behaviors. By thoroughly characterizing the compression profile, we can pinpoint the optimal compression force required to form a cohesive tablet without applying undue stress that could lead to capping — the separation of tablet tops during or after the compression phase.
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Convenience is a major priority in the pharmaceutical industry, because the easier and more convenient it is to take medication, the better. Stick pack packaging of pre-portioned products is the ideal primary packaging for this purpose. The LA600SP stick pack machine from Körber uses a side-loading process to package free-flowing powders, granules, pellets, and liquids for you. Up to 1,000 stick packs can be filled per minute.
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The XR75 Pharma X-ray is optimized for the quality control of pharmaceutical, nutraceutical, and cosmetic products in thin opaque packaging materials that cannot be inspected manually or with visual systems.
WHITE PAPERS AND CASE STUDIES
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Poultry Panic: Urgent Wastewater Fix Saves Poultry Plant From Fines
On a late Friday afternoon in June, a call came in to USP Technologies (USP): a major poultry processing plant in the southeast was in danger of violating their wastewater discharge permit.
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Lead Identification And Optimization For Computational Drug Discovery
AI-generated Fab molecules promise speed, but can computational designs actually express and bind at scale? A high-throughput screening workflow offers a data-backed answer.
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Scaling Global Vaccine Mega-Trials For A Top Five Pharma
See how high-volume enrollment, dynamic safety data capture, and rapid iteration can support global studies operating under intense timelines and scale.
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Mobile Clinical Lab For Miami Cancer Institute
Germfree helped the Miami Cancer Institute at the peak of the COVID pandemic convert a pharmacy compounding mobile unit to a BSL-2+ mobile clinical lab for in-house testing for COVID testing.
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Clinical Phase Manufacturing With A Self-Contained Cleanroom Facility
Explore the development of a mobile Biosafety Level 2+ (BSL-2+) facility adhering to cGMP for early-phase clinical trial manufacturing.
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Ophthalmic Product Package Inspection
Microscopic leaks in ophthalmic packaging can compromise sterility and patient safety. Learn how advanced vacuum decay testing delivers fast, reliable results, detecting defects as small as 5 microns.
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How Strategic Valve Installation Prevented Service Disruption at a Senior Living Facility
Learn how Hydra-Stop’s insertion valve provided new control points to mitigate future disruptions during a service line emergency.
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Recruiting High-Performing Sites To Beat Forecasted Trial Start Date
Explore a partnership that enabled Syneos Health to achieve its enrollment goals, increasing the likelihood of the study's success, and resulting in cost savings and maximized efficiency with minimal delays.
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12.5x Titer Boost Accelerates CAR-T Program To IND Filing
Plasmid engineering and process development boosted viral titer 12.5×, eliminating manufacturing bottlenecks and enabling an on‑time regulatory submission for the cell therapy program.
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Overcoming Participant Compliance Challenges In A Medical Device Study
Uncover how Catalyst Clinical Research enhanced participant compliance and streamlined scheduling for a TENS device study using the TrialKit platform, with crucial support from CDS.
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Lean Six Sigma Methodology Drives Cost Savings: 2 Success Stories
Unlock significant lab efficiency and financial gains. See how focused optimization of workflows and asset management led to substantial cost savings and reclaimed six-figure value in consumables.
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Meeting 100% Recruitment 7 Months Ahead Of Schedule
Uncover the detailed outcomes of this extensive Phase 3 clinical trial on a new biosimilar for non-small cell lung cancer.
NEWS
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Pocket Alarm Detects And Records RF/Microwave Directed Energy Weapons, Nuclear Events, And Terrestrial Gamma Bursts5/8/2025
Ultraview Corp’s EM/GAMMALERT is a new pocket device that warns of RF/microwave jammer and directed energy weapon deployment1 - an emerging threat speculated as a modality in “Havana Syndrome”.
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Redex Preloaded Systems Deliver Precise Positioning For Machine Tools1/16/2025
Redex is pleased to announce its patented DualDRIVE and TwinDRIVE preloading technologies now give CNC machine designers several ways to build a zero backlash system.
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Silo Pharma Expands Intellectual Property Portfolio With Patent Application For Exclusively Licensed Alzheimer's Drug4/28/2025
Silo Pharma, Inc. (Nasdaq: SILO) (“Silo” or the “Company”), a developmental stage biopharmaceutical company focused on novel therapeutics and drug delivery systems, today announced the filing of a patent application with the U.S. Patent and Trademark Office (USPTO) focused on the neurology drug SPC-14, an intranasal compound for the treatment of Alzheimer’s disease (AD) exclusively licensed to Silo Pharma from Columbia University.
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3-In-1 Orbital Thread Milling Cutters For New Thread Sizes1/14/2025
Following the successful introduction of the Thrill·tec TC645 Supreme orbital drill/thread mills for dimensions from M4 to M12 in 2023, Walter is now expanding its range to cover additional metric dimensions from M14 to M20 as well as their imperial equivalents.
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Be Part of Photonics Future: CIOE 2025 Visitor Registration Live Now!4/9/2025
The 26th China International Optoelectronic Exposition (CIOE 2025) is set to take place from September 10–12, 2025, at the Shenzhen World Exhibition & Convention Center, spanning 240,000 square meters of exhibition space.
ABOUT
About Nutrient Removal
Nutrient removal from wastewater consists of treating wastewater to remove nitrogen and phosphorus before it reenters natural waterways. High levels of nitrogen and phosphorus in wastewater cause eutrophication, a process where excess nutrients stimulate excessive plant growth such as algal blooms and cyanobacteria. The decomposition of the algae by bacteria uses up the oxygen in the water causing other organisms to die. This creates more organic matter for the bacteria to decompose. In addition, some algal blooms can produce toxins that contaminate drinking water supplies.
As authorized by the Clean Water Act, the National Pollutant Discharge Elimination System (NPDES) permit program regulates point sources, such as municipal wastewater treatment plants, that discharge pollutants as effluent into the waters of the United States. In recent years, many of the States’ environmental bodies have lowered nutrient limits to arrest eutrophication. Maryland’s effort to protect the Chesapeake Bay and its tidal tributaries is perhaps the most notable example of nutrient removal in the US. Nutrient removal continues to be a growing area of focus for wastewater treatment throughout the world.
The removal of nitrogen and phosphorus require different nutrient removal processes. To remove nitrogen, the nitrogen is oxidized from ammonia to become nitrate through a process called nitrification. This process is then followed by denitrification where the nitrate is reduced to nitrogen gas which is released to the atmosphere and removed from the wastewater.
Nitrification is a two-step aerobic process which typically takes place in aeration tanks. Denitrification requires anoxic conditions to encourage the appropriate biological conditions to form. The activated sludge process is often used to reduce nitrate to nitrogen gas in anoxic or denitrification tanks.
Phosphorus can be removed biologically using polyphosphate accumulating organisms (PAOs) which accumulate large quantities of phosphorus within their cells and separate it from treated water. Phosphorus removal can also be achieved by chemical removal. Once removed as sludge, phosphorus may be stored in a land fill. However, many municipalities and treatment facilities are looking to resell the biosolids for use in fertilizer.