RFICs

PRODUCTS

  • Five Critical Mistakes To Avoid In API Development And Manufacturing
    Highly Potent API (HPAPI) Handling

    Ensure safe and effective development of highly potent therapies with our proven expertise, specialized facilities, and robust containment systems designed to support every drug development stage.

  • Finwave - IMS 2024
    High-Performance, Broadband RF Switches Featuring GaN On Si Technology

    Finwave's high-performance, broadband RF switches utilize unique GaN on Si technology to offer a combination of fast switching and fast settling times, broadband operation, and robust power handling.

  • 79 Gal Inox Reactor
    Used 79 Gallon Inox Reactor

    Used 79 gallon (300 liter) Inox reactor, stainless steel construction, approximately 24" diameter x 34" straight side, dish lid top with dish bottom, jacket and interior rated 30 psi and full vacuum at 300 F, 6" top access, with (1) 4", (1) 3", (2) 2" and (2) 1.5" nozzles on top, with bottom entering magnetic agitator, .75 hp with controls, 1.5" center bottom outlet, with load cells, all on portable frame, serial# 95011-2, CRN# K82555, built 1995.

  • Natoli scientists
    Pharmaceutical Preformulation Support Services

    Partner with Natoli Scientific during the earliest stages. Our scientific expertise with state-of-the-art analytical capabilities is ready to take any preformulation challenge.

    Natoli scientific has an expertise of handling a wide range of APIs for the development of oral solids. We apply principles of ‘Quality by Design’ to define Critical Material Attributes (CMA), Critical Process Parameters (CPP), Critical Quality Attributes (CQA) and Quality Target Product Profiles (QTPP). Because we believe that understanding material and process as much as possible in the early life cycle of drug product development program is an insurance for further development path. Keeping your practices up to date with the ICHQ8 regulatory guidance issued by the US FDA. This is also a gate way for a smooth ride of product in the different stages of product development stages.

  • Used 15 Cu Ft AIM Pharmaceutical Ribbon Blender
    Used 15 Cu Ft AIM Pharmaceutical Ribbon Blender

    New 15 cu ft AIM Blending ribbon blender, model RB-15, 304 sanitary stainless steel construction with USDA grade #4 internal finish, 18 cu ft total capacity, 15 cu ft working capacity, approximately 25" wide x 48" long x 28" deep trough, double ribbon agitator, full hinged top cover, outboard roller bearings, sanitary split packing gland shaft seals, 6" center bottom outlet with manually operated slide gate discharge valve, 5 hp, 240/480 volt motor drive producing approximately 60 rpm shaft speed, on 304 stainless steel stand with approximately 17" discharge height, blender has been pre-wired for 240 volt, 3 phase, 60 hertz, including start/stop and E stop, serial# 015-411-SS-FG-RB-6S-2303-5VE, built 2023, New and Unused.

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About Nutrient Removal

Nutrient removal from wastewater consists of treating wastewater to remove nitrogen and phosphorus before it reenters natural waterways. High levels of nitrogen and phosphorus in wastewater cause eutrophication, a process where excess nutrients stimulate excessive plant growth such as algal blooms and cyanobacteria. The decomposition of the algae by bacteria uses up the oxygen in the water causing other organisms to die. This creates more organic matter for the bacteria to decompose. In addition, some algal blooms can produce toxins that contaminate drinking water supplies.

As authorized by the Clean Water Act, the National Pollutant Discharge Elimination System (NPDES) permit program regulates point sources, such as municipal wastewater treatment plants, that discharge pollutants as effluent into the waters of the United States. In recent years, many of the States’ environmental bodies have lowered nutrient limits to arrest eutrophication. Maryland’s effort to protect the Chesapeake Bay and its tidal tributaries is perhaps the most notable example of nutrient removal in the US. Nutrient removal continues to be a growing area of focus for wastewater treatment throughout the world.   

The removal of nitrogen and phosphorus require different nutrient removal processes. To remove nitrogen, the nitrogen is oxidized from ammonia to become nitrate through a process called nitrification. This process is then followed by denitrification where the nitrate is reduced to nitrogen gas which is released to the atmosphere and removed from the wastewater.

Nitrification is a two-step aerobic process which typically takes place in aeration tanks. Denitrification requires anoxic conditions to encourage the appropriate biological conditions to form. The activated sludge process is often used to reduce nitrate to nitrogen gas in anoxic or denitrification tanks.

Phosphorus can be removed biologically using polyphosphate accumulating organisms (PAOs) which accumulate large quantities of phosphorus within their cells and separate it from treated water. Phosphorus removal can also be achieved by chemical removal. Once removed as sludge, phosphorus may be stored in a land fill. However, many municipalities and treatment facilities are looking to resell the biosolids for use in fertilizer.